Antioxidants, Free Full-Text
Por um escritor misterioso
Last updated 03 julho 2024
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Endothelium-derived nitric oxide (NO)-induced vasodilation is impaired in pregnancy hypertension. However, the role of perivascular adipose tissue (PVAT)-derived hydrogen sulfide (H2S), as an alternative for counteracting vascular dysfunction, is incompletely clear in hypertensive disorders of pregnancy. Therefore, PVAT-derived H2S-induced vasodilation was investigated in pregnancy hypertension-induced endothelial dysfunction. Non-pregnant (Non-Preg) and pregnant (Preg) rats were submitted (or not) to the deoxycorticosterone (DOCA)-salt protocol and assigned as follows (n = 10/group): Non-Preg, Non-Preg+DOCA, Preg, and Preg+DOCA groups. Systolic blood pressure (SBP), angiogenesis-related factors, determinant levels of H2S (PbS), NO (NOx), and oxidative stress (MDA) were assessed. Vascular changes were recorded in thoracic aortas with PVAT and endothelium (intact and removed layers). Vasorelaxation responses to the substrate (L-cysteine) for the H2S-producing enzyme cystathionine-γ-lyase (CSE) were examined in the absence and presence of CSE-inhibitor DL-propargylglycine (PAG) in thoracic aorta rings pre-incubated with cofactor for CSE (pyridoxal-5 phosphate: PLP) and pre-contracted with phenylephrine. Hypertension was only found in the Preg+DOCA group. Preg+DOCA rats showed angiogenic imbalances and increased levels of MDA. PbS, but not NOx, showed increased levels in the Preg+DOCA group. Pre-incubation with PLP and L-cysteine elevated determinants of H2S in PVAT and placentas of Preg-DOCA rats, whereas no changes were found in the aortas without PVAT. Aortas of Preg-DOCA rats showed that PVAT-derived H2S-dependent vasodilation was greater compared to endothelium-derived H2S, whereas PAG blocked these responses. PVAT-derived H2S endogenously stimulated with the amino acid L-cysteine may be an alternative to induce vasorelaxation in endothelial dysfunction related to pregnancy hypertension.
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What Are Free Radicals And How Do They Affect Skin?
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Antioxidants Infographic Contain Sources Free Radical Stock Vector
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Antioxidants, What Are Antioxidants ?
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Free radicals: How do they affect the body?
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1 free radicals full by Transtellar Publications - Issuu
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Free Radicals and Antioxidants
Glutathione is one of our bodies main antioxidants which helps us
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Free Radicals and Antioxidants, Journal
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Structure-antioxidant activity relationship of methoxy, phenolic
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MISS SPA Face Mask Skin Care Replenishing & Repairing
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Free radicals, natural antioxidants, and their reaction mechanisms
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Antioxidants, Free Full-Text
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Natural antioxidants in processing and storage stability of sheep
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Antioxidants vs. Free Radicals: Plant Power for the win!
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