Cancers, Free Full-Text
Por um escritor misterioso
Last updated 06 julho 2024
![Cancers, Free Full-Text](https://pub.mdpi-res.com/cancers/cancers-13-06161/article_deploy/html/images/cancers-13-06161-g001.png?1638871814)
Overexpression of Exportin-1 (XPO1), a key regulator of nuclear-to-cytoplasmic transport, is associated with inferior patient outcomes across a range of adult malignancies. Targeting XPO1 with selinexor has demonstrated promising results in clinical trials, leading to FDA approval of its use for multiple relapsed/refractory cancers. However, XPO1 biology and selinexor sensitivity in childhood cancer is only recently being explored. In this review, we will focus on the differential biology of childhood and adult cancers as it relates to XPO1 and key cargo proteins. We will further explore the current state of pre-clinical and clinical development of XPO1 inhibitors in childhood cancers. Finally, we will outline potentially promising future therapeutic strategies for, as well as potential challenges to, integrating XPO1 inhibition to improve outcomes for children with cancer.
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2007/nejm_2007.356.issue-16/nejmsr070105/production/images/img_medium/nejmsr070105_f1.jpeg)
The Decrease in Breast-Cancer Incidence in 2003 in the United
![Cancers, Free Full-Text](https://pub.mdpi-res.com/cancers/cancers-15-01922/article_deploy/html/images/cancers-15-01922-g001-550.jpg?1679559435)
Patch Para Alh Get File - Colaboratory
![Cancers, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2022/nejm_2022.387.issue-2/nejmoa2204619/20221114/images/img_small/nejmoa2204619_f0.jpeg)
Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C
![Cancers, Free Full-Text](https://www.freemefromlungcancer.org/wp-content/uploads/2019/01/Logo-Free-Me-Logo-Form-Lung-Cancer-sm.png)
Home - Free ME from Lung Cancer
![Cancers, Free Full-Text](https://acsjournals.onlinelibrary.wiley.com/cms/asset/d148c6d9-0517-49d2-8d6e-8c89673f6ef2/caac21731-fig-0001-m.jpg)
Cancer treatment and survivorship statistics, 2022 - Miller - 2022
![Cancers, Free Full-Text](https://www.mdpi.com/cancers/cancers-05-01469/article_deploy/html/images/cancers-05-01469-g003-1024.png)
Cancers, Free Full-Text
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Multimodal analysis of methylomics and fragmentomics in plasma
![Cancers, Free Full-Text](https://i1.rgstatic.net/publication/353155214_Combination_of_tumor_markers_predicts_progression_and_pathological_response_in_patients_with_locally_advanced_gastric_cancer_after_neoadjuvant_chemotherapy_treatment/links/60e9d56430e8e50c01f8067d/largepreview.png)
PDF) Combination of tumor markers predicts progression and
from Flow Cytometry to Cytomics, Page 2
![Cancers, Free Full-Text](https://i1.rgstatic.net/publication/262789223_Predictors_of_recurrence_free_survival_for_patients_with_stage_II_and_III_colon_cancer/links/55915fe308ae47a349109c94/largepreview.png)
PDF) Predictors of recurrence free survival for patients with
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