Cancers, Free Full-Text
Por um escritor misterioso
Last updated 05 julho 2024
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Transforming growth factor-beta (TGFB) is a critical regulator of normal haematopoiesis. Dysregulation of the TGFB pathway is associated with numerous haematological malignancies including myelofibrosis, acute myeloid leukaemia, and lymphoid disorders. TGFB has classically been seen as a negative regulator of proliferation in haematopoiesis whilst stimulating differentiation and apoptosis, as required to maintain homeostasis. Tumours frequently develop intrinsic resistant mechanisms to homeostatic TGFB signalling to antagonise its tumour-suppressive functions. Furthermore, elevated levels of TGFB enhance pathogenesis through modulation of the immune system and tumour microenvironment. Here, we review recent advances in the understanding of TGFB signalling in B-cell malignancies with a focus on the tumour microenvironment. Malignant B-cells harbour subtype-specific alterations in TGFB signalling elements including downregulation of surface receptors, modulation of SMAD signalling proteins, as well as genetic and epigenetic aberrations. Microenvironmental TGFB generates a protumoural niche reprogramming stromal, natural killer (NK), and T-cells. Increasingly, evidence points to complex bi-directional cross-talk between cells of the microenvironment and malignant B-cells. A greater understanding of intercellular communication and the context-specific nature of TGFB signalling may provide further insight into disease pathogenesis and future therapeutic strategies.
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Join a FREE Breast Cancer Survivorship Program
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Sotorasib for Lung Cancers with KRAS p.G12C Mutation
Our cancer year : Brabner, Joyce : Free Download, Borrow, and Streaming : Internet Archive
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Cancer Free – Heaven Sent Greeting Cards
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Thoracic Cancer - Wiley Online Library
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Cancers, Free Full-Text
Journal of Cancer Research and Clinical Oncology
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Cancer Awareness Word Search – Free Printable
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Cell-free nucleic acids as biomarkers in cancer patients
from Flow Cytometry to Cytomics, Page 2
Information and Resources about for Cancer: Breast, Colon, Lung, Prostate, Skin
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Cancers, Free Full-Text
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