Cells, Free Full-Text
Por um escritor misterioso
Last updated 05 julho 2024
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Identifying tissue-specific molecular signatures of active regulatory elements is critical to understanding gene regulatory mechanisms. In this study, transcription start sites (TSS) and enhancers were identified using Cap analysis of gene expression (CAGE) across endometrial stromal cell (ESC) samples obtained from women with (n = 4) and without endometriosis (n = 4). ESC TSSs and enhancers were compared to those reported in other tissue and cell types in FANTOM5 and were integrated with RNA-seq and ATAC-seq data from the same samples for regulatory activity and network analyses. CAGE tag count differences between women with and without endometriosis were statistically tested and tags within close proximity to genetic variants associated with endometriosis risk were identified. Over 90% of tag clusters mapping to promoters were observed in cells and tissues in FANTOM5. However, some potential cell-type-specific promoters and enhancers were also observed. Regions of open chromatin identified using ATAC-seq provided further evidence of the active transcriptional regions identified by CAGE. Despite the small sample number, there was evidence of differences associated with endometriosis at 210 consensus clusters, including IGFBP5, CALD1 and OXTR. ESC TSSs were also located within loci associated with endometriosis risk from genome-wide association studies. This study provides novel evidence of transcriptional differences in endometrial stromal cells associated with endometriosis and provides a valuable cell-type specific resource of active TSSs and enhancers in endometrial stromal cells.
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The emerging impact of cell-free chemical biosynthesis - ScienceDirect
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Cell-Free DNA and Apoptosis: How Dead Cells Inform About the Living - ScienceDirect
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Sequencing of Circulating Cell-free DNA during Pregnancy
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Cell-free gene expression: an expanded repertoire of applications
Full-spectrum cell-free RAN for 6G systems: s
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JCM, Free Full-Text
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Antibodies, Free Full-Text
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Towards reproducible cell-free systems
Nature Reviews Molecular Cell Biology on X: From May cover Challenges and directions in studying cell–cell communication by #ExtracellularVesicles @DaveCarter1234 @guillaume_niel @VaderPieter Clayton Lambert & Raposo #EVsAreCool FREE pdf: https
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Cell-free mutant analysis combined with structure prediction of a lasso peptide biosynthetic protein B2
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IJMS, Free Full-Text
Cell-Free Protein Expression
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IJMS, Free Full-Text
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STEM CELLS: Vol 35, No 5
Mol Imaging Radionucl Ther on X: The Role of a Bone SPECT/CT Scan in the Follow-up of a Solitary Bone Lesion in a Patient with Langerhans' Cell Histiocytosis You can see the
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