GPC2-CAR T cells tuned for low antigen density mediate potent

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Last updated 18 junho 2024

GPC2-CAR T cells tuned for low antigen density mediate potent

Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets. We developed T cell…

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice - ScienceDirect

CD276-CAR T cells and Dual-CAR T cells targeting CD276/FGFR4 promote rhabdomyosarcoma clearance in orthotopic mouse models, Journal of Experimental & Clinical Cancer Research

CAR T cells targeting tumor-associated exons of glypican 2 regress neuroblastoma in mice. - Abstract - Europe PMC

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Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity - ScienceDirect

IJMS, Free Full-Text

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

Improving CAR-T immunotherapy: Overcoming the challenges of T cell exhaustion - eBioMedicine

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