Genes, Free Full-Text
Por um escritor misterioso
Last updated 26 junho 2024
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Background: Hemochromatosis is a genetic condition of iron overload caused by deficiency of hepcidin. In a previous stage of this study, patients with suspected hemochromatosis had their quality of life (QL) measured. We observed that QL scores differed among genotypic groups of patients. In this reported final phase of the study, the aims were to compare QL scores after a treatment period of approximately 3 years and to analyze a possible association of the serum ferritin values with QL scores. Methods: Sixty-five patients were enrolled in this final phase and divided into group 1 (patients that showed primary iron overload and homozygous genotype for the HFE p.Cys282Tyr mutation) and group 2 (other kinds of genotypes). Short Form 36 (SF-36) was performed and consisted of eight domains with a physical and also a mental component. Results: Both groups had a significant decrease in serum ferritin concentrations: group 1 had a variation from 1844 ± 1313 ng/mL to 281 ± 294 ng/mL, and group 2 had a variation from 1216 ± 631 ng/mL to 236 ± 174 ng/mL. Group 1 had a smaller mean value for these six SF-36 domains compared with group 2, indicating a worse QL. Conclusions: In this final stage, six domains demonstrated a difference among genotypic groups (role emotional and mental health, adding to the four of the initial phase), reassuring the impact of the identified genotype on the QL of hemochromatosis patients. Furthermore, despite that both patient groups demonstrated similar and significant decreases in serum ferritin values, no association was found between the decrease in this biological parameter and the SF-36 domains.
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Genes, Free Full-Text
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Toxins, Free Full-Text
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Inferring Phylogenies Felsenstein Pdf Download - Colaboratory
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Genes April 2022 - Browse Articles
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Cs 1.6 Lj Cj Script - Colaboratory
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Genes, Free Full-Text
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Towards complete and error-free genome assemblies of all vertebrate species
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Genes, Free Full-Text
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Genes, Free Full-Text
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Philosophies, Free Full-Text
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Basu Basu Pardesi Nenu Song Free - Colaboratory
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Multi-context genetic modeling of transcriptional regulation resolves novel disease loci
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Evolutionary analysis of a complete chicken genome
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Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values
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