Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
Por um escritor misterioso
Last updated 05 julho 2024
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-023-39261-3/MediaObjects/41467_2023_39261_Fig1_HTML.png)
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.itinerare.uzh.ch/dam/jcr:90b4b2ea-bce5-42ea-89de-68589e28e5d0/MERH.jpg)
News, URPP ITINERARE
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41467-023-39261-3/MediaObjects/41467_2023_39261_Fig2_HTML.png)
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.biorxiv.org/content/biorxiv/early/2023/02/22/2022.08.28.505580/F2.large.jpg)
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://media.cellsignal.com/product/image/9644_fig01_W_10_20210423082238.png)
4E-BP1 (53H11) Rabbit mAb Cell Signaling Technology
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41467-023-39261-3/MediaObjects/41467_2023_39261_Fig1_HTML.png)
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.researchgate.net/publication/358509261/figure/fig4/AS:1140231709442050@1648863832923/Cystine-crystals-and-enlarged-lysosomes-in-proximal-tubules-of-cystinotic-rats-A.jpg)
Cystine crystals and enlarged lysosomes in proximal tubules of
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.researchgate.net/publication/281143669/figure/fig8/AS:667206455140379@1536085823838/Sox9-Is-Upregulated-in-the-Proximal-Tubules-Early-after-Acute-Kidney-Injury.jpg)
Sox9 Is Upregulated in the Proximal Tubules Early after Acute Kidney Injury
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.researchgate.net/publication/281143669/figure/fig12/AS:667206459338761@1536085824323/Fate-Mapping-of-Sox9-Cell-Descendants-Shows-Extensive-Contribution-to-the-Ureteric-and.jpg)
Fate Mapping of Sox9 + Cell Descendants Shows Extensive Contribution to
Full article: The CTNS-MTORC1 axis couples lysosomal cystine to epithelial cell fate decisions and is a targetable pathway in cystinosis
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://media.springernature.com/w290h158/springer-static/image/art%3A10.1038%2Fs41467-023-39261-3/MediaObjects/41467_2023_39261_Fig1_HTML.png)
From molecules and cells to organisms
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.itinerare.uzh.ch/dam/jcr:891c3489-6574-41b5-998e-c39cd4b93249/itinerare_NEW%20LOGO_cut.jpg)
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![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41467-023-39261-3/MediaObjects/41467_2023_39261_Fig9_HTML.png)
Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.researchgate.net/publication/344001859/figure/fig3/AS:930825507975172@1598937503199/HDX-MS-difference-of-SLC38A9NT-reveals-pre-GAP-complex-dynamics-a-HDX-difference-plot-of.png)
HDX-MS difference of SLC38A9NT reveals pre-GAP complex dynamics a, HDX
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.frontiersin.org/files/Articles/1235716/fcell-11-1235716-HTML/image_m/fcell-11-1235716-g001.jpg)
Frontiers Emerging roles of proximal tubular endocytosis in renal fibrosis
![Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization](https://www.researchgate.net/publication/322402995/figure/fig2/AS:614009095073792@1523402584318/A-working-model-depicting-the-link-between-defective-lysosome-autophagy-pathways-and.png)
A working model depicting the link between defective lysosome-autophagy
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