Pathogens, Free Full-Text
Por um escritor misterioso
Last updated 04 julho 2024
![Pathogens, Free Full-Text](https://www.mdpi.com/pathogens/pathogens-10-00121/article_deploy/html/images/pathogens-10-00121-g001-550.jpg)
Acute chagasic encephalitis is a clinically severe central nervous system (CNS) manifestation. However, the knowledge of the nervous form of Chagas disease is incomplete. The role of the muscarinic acetylcholine receptor (mAChR) on mice behavior and brain lesions induced by Trypanosoma cruzi (Colombian strain) was herein investigated in mice treated with the mAChR agonist and antagonist (carbachol and atropine), respectively. Immunosuppressed or non-immunosuppressed mice were intracerebroventricularly (icv) or intraperitoneally (ip) infected. All groups were evaluated 15 d.p.i. (days post infection). Intraperitoneally infected animals had subpatent parasitemia. Patent parasitemia occurred only in icv infected mice. The blockade of mAChR increased the parasitemia, parasitism and lesions compared to its activation. Infected not treated (INT ip) mice did not present meningitis and encephalitis, regardless of immunosuppression. INT icv brains presented higher cellularity, discrete signs of cellular degeneration, frequent presence of parasites and focal meningitis. The immunosuppressed atropine + icv mice presented increased intracellular parasitism associated with degenerative parenchymal changes, while carbachol + icv mice presented discrete meningitis, preservation of the cortex and absence of relevant parasitism. Cholinergic receptor blockage increased impairment of coordination vs. receptor activation. Muscarinic cholinergic pathway seems to be involved in immune mediated cell invasion events while its blockade favored infection evolution, brain lesions, and behavioral alterations.
![Pathogens, Free Full-Text](http://cercetare.bio.uaic.ro/grupuri/bioactive/content/grants/ped2020/article.png)
BioActive Group - Research
![Pathogens, Free Full-Text](https://iiif.elifesciences.org/lax/68874%2Felife-68874-fig2-v1.tif/full/1500,/0/default.jpg)
Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm
![Pathogens, Free Full-Text](https://i.ytimg.com/vi/WsZS4RCWpcE/maxresdefault.jpg)
What Are Pathogens?, Health, Biology
![Pathogens, Free Full-Text](http://libna.mntl.illinois.edu/images/research_images/2014/LAMPFET.jpg)
Detection of Viable Pathogens Using Label-Free Electrical Detection of Nucleic Acid Amplification : LIBNA
![Pathogens, Free Full-Text](https://www.frontiersin.org/files/Articles/801892/fmicb-13-801892-HTML/image_m/fmicb-13-801892-g001.jpg)
Frontiers Bacterial Species Associated With Human Inflammatory Bowel Disease and Their Pathogenic Mechanisms
![Pathogens, Free Full-Text](https://www.nejm.org/na101/home/literatum/publisher/mms/journals/content/nejm/2010/nejm_2010.362.issue-19/nejmra0904124/production/images/img_medium/nejmra0904124_f1.jpeg)
Hospital-Acquired Infections Due to Gram-Negative Bacteria
![Pathogens, Free Full-Text](https://www.pnas.org/cms/10.1073/pnas.2209607119/asset/10a02537-b81e-466a-930b-7d6e48bd5133/assets/images/large/pnas.2209607119fig03.jpg)
A culture-free biphasic approach for sensitive and rapid detection of pathogens in dried whole-blood matrix
What is a pathogen? - 4-H Animal Science
![Pathogens, Free Full-Text](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41579-022-00745-6/MediaObjects/41579_2022_745_Fig1_HTML.png)
Nutritional immunity: the battle for nutrient metals at the host–pathogen interface
![Pathogens, Free Full-Text](https://ars.els-cdn.com/content/image/1-s2.0-S0269749117340332-fx1.jpg)
Sulfadiazine/ciprofloxacin promote opportunistic pathogens occurrence in bulk water of drinking water distribution systems - ScienceDirect
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