Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals
Por um escritor misterioso
Last updated 05 julho 2024
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.jneurosci.org/content/jneuro/26/10/2661/F5.large.jpg)
Sporadic amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects particularly motoneurons. Several pieces of evidence suggested the involvement of autoimmune mechanisms mediated by antibodies in ALS. However, the significance of those antibodies in the disease and the underlying mechanisms are unknown. Here we showed that IgG purified from a group of sporadic ALS patients, but not familial ALS patients, specifically interact with the presynaptic membrane of motoneurons through an antigen–antibody interaction and modulated synaptic transmission. Immunoreactivity against nerve terminals showed strong correlation with synaptic modulation ability. In addition, several controls have ruled out the possibility for this synaptic modulation to be mediated through proteases or nonspecific effects. Effective IgG potentiated both spontaneous and asynchronous transmitter release. Application of pharmacological inhibitors suggested that activation of this increased release required a nonconstitutive Ca2+ influx through N-type (Cav2.2) channels and phospholipase C activity and that activation of IP3 and ryanodine receptors were necessary to both activate and sustain the increased release. Consistent with the notion that ALS is heterogeneous disorder, our results reveal that, in ∼50% of ALS patients, motor nerve terminals constitutes a target for autoimmune response.
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2F1750-1326-4-20/MediaObjects/13024_2009_Article_84_Fig1_HTML.jpg)
Calcium signaling in neurodegeneration
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://journals.physiology.org/cms/10.1152/physrev.00006.2016/asset/images/medium/z9j0041627730007.jpeg)
The Inositol Trisphosphate/Calcium Signaling Pathway in Health and
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fnrn.2015.27/MediaObjects/41583_2016_Article_BFnrn201527_Fig1_HTML.jpg)
Autoimmune synaptopathies Nature Reviews Neuroscience
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.frontiersin.org/files/Articles/683609/fcell-09-683609-HTML/image_m/fcell-09-683609-g001.jpg)
Frontiers HGF and MET: From Brain Development to Neurological
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.mdpi.com/cells/cells-11-03143/article_deploy/html/images/cells-11-03143-g001.png)
Cells, Free Full-Text
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.jneurosci.org/content/jneuro/26/34/8774/F3.large.jpg)
Complete Dissociation of Motor Neuron Death from Motor Dysfunction
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://pub.mdpi-res.com/ijms/ijms-20-02818/article_deploy/html/images/ijms-20-02818-g002.png?1571662853)
IJMS, Free Full-Text
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://ars.els-cdn.com/content/image/1-s2.0-S0896627306007252-gr3.jpg)
ALS: A Disease of Motor Neurons and Their Nonneuronal Neighbors
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.mdpi.com/cells/cells-10-01789/article_deploy/html/images/cells-10-01789-g001.png)
Cells, Free Full-Text
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.frontiersin.org/files/Articles/1277399/fnins-17-1277399-HTML/image_m/fnins-17-1277399-g003.jpg)
Frontiers Immunology of amyotrophic lateral sclerosis – role of
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://www.futuremedicine.com/cms/10.2217/fvl-2023-0105/asset/images/medium/figure3.gif)
Altered synaptic plasticity: plausible mechanisms associated with
![Calcium Signaling Pathways Mediating Synaptic Potentiation Triggered by Amyotrophic Lateral Sclerosis IgG in Motor Nerve Terminals](https://media.springernature.com/m685/springer-static/image/art%3A10.1186%2Fs12974-016-0538-2/MediaObjects/12974_2016_538_Fig1_HTML.gif)
Complement activation at the motor end-plates in amyotrophic
Recomendado para você
-
NEON FEAR05 julho 2024
-
Premium Photo Express covid-19 test for igm and igg antibodies to novel coronavirus sars-cov-2, covid-19. nurse hand in glove collects patient blood with disposable pipette. purple neon background.05 julho 2024
-
The Best is Yet to Come Chrome Balloon Sticker by mia-igg05 julho 2024
-
Igg vector hi-res stock photography and images - Alamy05 julho 2024
-
mNeonGreen antibody (29523-1-AP)05 julho 2024
-
NEW SEALED) Doug TenNapel signed BIGFOOT BILL GN + sketchbook IGG Backer Perks!05 julho 2024
-
Cute Immunology Lanyard Immune Cells Antibodies Science05 julho 2024
-
Effect of co-overexpression of the cargo receptor ERGIC-53/MCFD2 on antibody production and intracellular IgG secretion in recombinant Chinese hamster ovary cells - ScienceDirect05 julho 2024
-
100pcs Finishing Nails Hand-Drive Hardware Carbon Steel Nail 25mm 1-inches : Industrial & Scientific05 julho 2024
-
Express Covid Test Igm Igg Antibodies Novel Coronavirus Sars Cov Stock Photo by ©anyaivanova@gmail.com 37779084605 julho 2024
você pode gostar
-
Minos Dummy, Roblox Item Asylum Wiki05 julho 2024
-
How to make Roronoa Zoro from One Piece in Roblox! (Loguetown and05 julho 2024
-
female sapnap-dream smp Minecraft Skin05 julho 2024
-
Sunday Night Funkin FNF Mod mobile android iOS-TapTap05 julho 2024
-
THE MAN FROM THE WINDOW05 julho 2024
-
Create your own Avatar!05 julho 2024
-
Decoding Keyser Söze's Ingenious Strategies for Achieving His Targets, by Shahzad Murad05 julho 2024
-
Volante Logitech G923, PS5, PS4, PC com Force Feedback TRUEFORCE - 941-00014805 julho 2024
-
Top 10 Melhores Cartões Bradesco em 2023 (Elo, Visa e mais)05 julho 2024
-
TJoC Ignited Collection Theme05 julho 2024